RCC1 rabbit pAb

• Background :

  Disease:Patients with Raynaud disease produce antibodies that bind to RCC1., function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA., similarity:Contains 7 RCC1 repeats., subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.

• Description :

  Disease: Patients with Raynaud disease produce antibodies that bind to RCC1. function: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. similarity: Contains 7 RCC1 repeats. subcellular location: Becomes dispersed throughout the cytoplasm during mitosis.

• UniProt :

  P18754

• Swiss Prot :

  P18754

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthetic peptide from human protein at AA range: 301-350

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000

• Molecular Weight :

  45kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  45kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828) . Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449) . .

• Other Product Names :

  RCC1 CHC1

• Gene ID (Human) :

  1104