RCC2 rabbit pAb

CAT: 0855-ES6811-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6811-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 7 RCC1 repeats., subcellular location:Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex., subunit:Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
Description
Function: Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 7 RCC1 repeats. subcellular location: Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex. subunit: Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.
UniProt
Q9P258
Swiss Prot
Q9P258
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RCC2. AA range:473-522
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
56kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
56kD
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Nucleus . Cytoplasm, cytoskeleton . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle . Chromosome . Midbody . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378) . Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455) . Colocalizes with RAC1 at the cell membrane (PubMed:25074804) . .
Other Product Names
RCC2; KIAA1470; TD60; Protein RCC2; RCC1-like protein TD-60; Telophase disk protein of 60 kDa
Gene ID (Human)
55920

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