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Otubain-1 rabbit pAb

CAT: 0855-ES8361-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8361-01Size:50 µL
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Background
OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1) Homo sapiens The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Description
OTU deubiquitinase, ubiquitin aldehyde binding 1 (OTUB1) Homo sapiens The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits Cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008],
Product Name Alternative
OTUB1; OTB1; OTU1; HSPC263; Ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1
UniProt
Q96FW1
Swiss Prot
Q96FW1
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from Otubain-1 . at AA range: 20-100
Target
Otubain-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
31kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
31kD
Fragment
IgG
Subcellular Location
Cytoplasm .
Other Product Names
OTUB1; OTB1; OTU1; HSPC263; Ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1
Gene ID (Human)
55611

UniProtKB · Q96FW1

Ubiquitin thioesterase OTUB1

OTUB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96FW1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OTUB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.19.12
Processing
—
Secondary accessions
Q32Q78, Q96II3, Q9NXQ4, Q9P0B8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Adaptive immunityDNA damageDNA repairImmunityUbl conjugation pathway

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Molecular function

HydrolaseProteaseThiol protease

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