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Synphilin-1 rabbit pAb

CAT: 0855-ES3536-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Description
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Product Name Alternative
SNCAIP; Synphilin-1; Sph1; Alpha-synuclein-interacting protein
UniProt
Q9Y6H5
Swiss Prot
Q9Y6H5
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Synphilin-1. AA range:797-846
Target
Synphilin-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
100kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
100kD
Fragment
IgG
Subcellular Location
Cytoplasm . Detected in cytoplasmic inclusion bodies, together with SNCA.
Other Product Names
SNCAIP; Synphilin-1; Sph1; Alpha-synuclein-interacting protein
Gene ID (Human)
9627

UniProtKB · Q9Y6H5

Synphilin-1

SNCAP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6H5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNCAIP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Sph1
EC number
—
Processing
—
Secondary accessions
D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

ANK repeatCoiled coilRepeat

Cellular component

Cytoplasm

Disease

NeurodegenerationParkinson diseaseParkinsonism

PTM

Ubl conjugation

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