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Repac rabbit pAb

CAT: 0855-ES8099-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8099-02Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]) .[supplied by OMIM, Mar 2008]
Description
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al. 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008],
Product Name Alternative
RAPGEF5; GFR; KIAA0277; MRGEF; Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac
UniProt
Q92565
Swiss Prot
Q92565
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RAPGEF5. AA range:431-480
Target
Repac
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Nucleus.
Other Product Names
RAPGEF5; GFR; KIAA0277; MRGEF; Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac
Gene ID (Human)
9771

UniProtKB · Q92565

Rap guanine nucleotide exchange factor 5

RPGF5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92565
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RAPGEF5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A4D140, Q8IXU5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Guanine-nucleotide releasing factor

Cellular component

Nucleus

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