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Microcephalin rabbit pAb

CAT: 0855-ES7588-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7588-02Size:100 µL
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Background
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Description
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],
UniProt
Q8NEM0
Swiss Prot
Q8NEM0
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MCPH1. AA range:91-140
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
93kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
93kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Other Product Names
MCPH1; Microcephalin
Gene ID (Human)
79648

UniProtKB · Q8NEM0

Microcephalin

MCPH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NEM0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MCPH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A075B6F8, B4DWW2, E9PGU5, E9PH63, Q66GU1, Q9H9C7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoskeleton

Disease

Intellectual disabilityPrimary microcephaly

PTM

Phosphoprotein

Domain

Repeat

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