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RO60 rabbit pAb

CAT: 0855-ES7287-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7287-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign., function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the Ro 60 kDa family., similarity:Contains 1 TROVE domain., subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
Description
Disease: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign. function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the Ro 60 kDa family. similarity: Contains 1 TROVE domain. subunit: Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
Product Name Alternative
TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2
UniProt
P10155
Swiss Prot
P10155
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TROVE2. AA range:311-360
Target
RO60
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
Other Product Names
TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2
Gene ID (Human)
6738

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