RANTES rabbit pAb

CAT: 0855-ES7129-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES7129-02Size:100 µL

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Background

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode

Description

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This Cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode

UniProt

P13501

Swiss Prot

P13501

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human RANTES. AA range:35-84

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Secreted.

Other Product Names

CCL5; D17S136E; SCYA5; C-C motif chemokine 5; EoCP; Eosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; TCP228; T-cell-specific protein RANTES

Gene ID (Human)

6352

UniProtKB · P13501

C-C motif chemokine 5

CCL5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P13501
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CCL5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondGlycoproteinOxidation

Cellular component

Secreted

Domain

Signal

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Alternative Products

Catalog	Name
GTR18322184-01	RANTES Rabbit mAb
MBS8543628-01	RANTES Rabbit pAb
GTR18102661	RANTES Rabbit Polyclonal Antibody
A5630-01	CCL5/RANTES Rabbit pAb
BS40701-01	RANTES Rabbit monoclonal antibody
C59622	Conjugated RANTES Rabbit mAb
GTR18334733-01	RANTES Rabbit mAb Antibody
E2RB20094UC	RANTES Rabbit mAb, capture
RRF424	Anti-Rat RANTES (Rabbit)
SLM-54125R-01	Rabbit Anti-RANTES antibody