(RS) -4CPG

• Description:

  (RS) -4CPG ((RS) -4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS) -4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1 (-/-) mice and 116.9±1.8% (n = 5) in IP3R1 (+/+) mice.

• Product Name Alternative:

  (RS) -4-Carboxyphenylglycine

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/rs-4cpg.html

• Purity:

  99.04

• Smiles:

  O=C(O)C(N)C1=CC=C(C(O)=O)C=C1

• Molecular Formula:

  C9H9NO4

• Molecular Weight:

  195.17

• Precautions:

  H302

• References & Citations:

  [1]Neuronal plasticity in hippocampal mossy fiber-CA3 synapses of mice lacking the inositol-1,4,5-trisphosphate type 1 receptor

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [7292-81-1]