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RFWD3 rabbit pAb

CAT: 0855-ES6711-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6711-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 RING-type zinc finger., similarity:Contains 3 WD repeats.
Description
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 RING-type zinc finger. similarity: Contains 3 WD repeats.
UniProt
Q6PCD5
Swiss Prot
Q6PCD5
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human RFWD3. AA range:374-423
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, PML body . Cytoplasm . In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies (PubMed:21558276) . In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair (PubMed:21504906, PubMed:28575657) . This recruitment depends upon RPA2 (PubMed:21504906) . .
Other Product Names
RFWD3; RNF201; E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201
Gene ID (Human)
55159

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