BCAS3 rabbit pAb
CAT:
855-ES6677-02
Size:
100 μL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BCAS3 rabbit pAb
- Description: Developmental stage: Fetal. Disease: A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23;q13) with BCAS4. similarity: Belongs to the WD repeat BCAS3 family. similarity: Contains 3 WD repeats. tissue specificity: Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.
- Synonyms: BCAS3; Breast carcinoma-amplified sequence 3; GAOB1
- Gene ID: 54828
- UniProt: Q9H6U6
- Cellular Locus: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Preautophagosomal structure. Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712)..
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: Synthesized peptide derived from BCAS3 . at AA range: 660-740
- Clonality: Polyclonal
- Validated Applications: WB, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
- Molecular Weight: 100kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.