ATG4b Rabbit rabbit pAb

ATG4b Rabbit rabbit pAb

• Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
• Synonyms: Cysteine protease ATG4B (EC 3.4.22.-;AUT-like 1 cysteine endopeptidase;Autophagin-1;Autophagy-related cysteine endopeptidase 1;Autophagy-related protein 4 homolog B;hAPG4B)
• Gene ID: 23192
• UniProt: Q9Y4P1
• Cellular Locus: Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum. Mitochondrion. Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041). A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041)..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant Protein of ATG4b
• Clonality: Polyclonal
• Validated Applications: IHC, IF
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1:50-300
• Molecular Weight: 44kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.