BCAS3 rabbit pAb

• Background:

  Developmental stage:Fetal., disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23; q13) with BCAS4., similarity:Belongs to the WD repeat BCAS3 family., similarity:Contains 3 WD repeats., tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.

• Description:

  Developmental stage: Fetal. Disease: A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23;q13) with BCAS4. similarity: Belongs to the WD repeat BCAS3 family. similarity: Contains 3 WD repeats. tissue specificity: Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.

• UniProt:

  Q9H6U6

• Swiss Prot:

  Q9H6U6

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from BCAS3 . at AA range: 660-740

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight:

  100kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  100kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Preautophagosomal structure . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity) . Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712) . .

• Other Product Names:

  BCAS3; Breast carcinoma-amplified sequence 3; GAOB1

• Gene ID (Human):

  54828