BCAS3 rabbit pAb

CAT: 0855-ES6677-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6677-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Developmental stage:Fetal., disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23; q13) with BCAS4., similarity:Belongs to the WD repeat BCAS3 family., similarity:Contains 3 WD repeats., tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.
Description
Developmental stage: Fetal. Disease: A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17;20) (q23;q13) with BCAS4. similarity: Belongs to the WD repeat BCAS3 family. similarity: Contains 3 WD repeats. tissue specificity: Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.
Product Name Alternative
BCAS3; Breast carcinoma-amplified sequence 3; GAOB1
UniProt
Q9H6U6
Swiss Prot
Q9H6U6
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from BCAS3 . at AA range: 660-740
Target
BCAS3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
100kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
100kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Preautophagosomal structure . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity) . Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712) . .
Other Product Names
BCAS3; Breast carcinoma-amplified sequence 3; GAOB1
Gene ID (Human)
54828

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