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MARCH2 rabbit pAb

CAT: 0855-ES6507-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6507-02Size:100 µL
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Background
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19) . MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]) .[supplied by OMIM, Mar 2010]
Description
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6. 3. 2. 19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al. 2004 [PubMed 14722266]; Nakamura et al. 2005 [PubMed 15689499]). [supplied by OMIM, Mar 2010],
Product Name Alternative
MARCH2; RNF172; HSPC240; E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172
UniProt
Q9P0N8
Swiss Prot
Q9P0N8
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MARCH2. AA range:191-240
Target
MARCH2
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasm . Cell membrane ; Multi-pass membrane protein .
Other Product Names
MARCH2; RNF172; HSPC240; E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172
Gene ID (Human)
51257

UniProtKB · Q9P0N8

E3 ubiquitin-protein ligase MARCHF2

MARH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9P0N8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MARCHF2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A6NP10, Q5H785, Q8N5A3, Q96B78
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembrane

Biological process

EndocytosisUbl conjugation pathway

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helixZinc-finger

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