MARK2 rabbit pAb

• Background:

  Microtubule affinity regulating kinase 2 (MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

• Description:

  Microtubule affinity regulating kinase 2 (MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],

• UniProt:

  Q7KZI7

• Swiss Prot:

  Q7KZI7

• Reactivity:

  Human; Mouse; Rat; Monkey

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human MARK2. AA range:10-59

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  85kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  85kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite . Cytoplasm . Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.

• Other Product Names:

  MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b; Par-1b; Par1b

• Gene ID (Human):

  2011