MARCH5 rabbit pAb

• Background:

  MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]) .[supplied by OMIM, Mar 2008]

• Description:

  MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al. 2006 [PubMed 16936636]). [supplied by OMIM, Mar 2008],

• UniProt:

  Q9NX47

• Swiss Prot:

  Q9NX47

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human MARCH5. AA range:21-70

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IF; WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  37kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  37kD

• Fragment:

  IgG

• Subcellular Location:

  Mitochondrion outer membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266) . Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301) . .

• Other Product Names:

  MARCH5; RNF153; E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153

• Gene ID (Human):

  54708