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Sclerostin rabbit pAb

CAT: 0855-ES6491-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6491-01Size:50 µL
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Background
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
Description
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],
Product Name Alternative
SOST; Sclerostin
UniProt
Q9BQB4
Swiss Prot
Q9BQB4
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from Sclerostin . at AA range: 130-210
Target
Sclerostin
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
26kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix .
Other Product Names
SOST; Sclerostin
Gene ID (Human)
50964

UniProtKB · Q9BQB4

Sclerostin

SOST_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BQB4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOST
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q495N9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Cellular component

Extracellular matrixSecreted

Molecular function

Heparin-binding

Domain

Signal

Biological process

Wnt signaling pathway

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E47R10200Sclerostin Rabbit pAb
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