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PCB rabbit pAb

CAT: 0855-ES6488-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6488-02Size:100 µL
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Background
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Description
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],
Product Name Alternative
PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB
UniProt
P11498
Swiss Prot
P11498
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PC. AA range:357-406
Target
PCB
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
120kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
120kD
Fragment
IgG
Subcellular Location
Mitochondrion matrix .
Other Product Names
PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB
Gene ID (Human)
5091

UniProtKB · P11498

Pyruvate carboxylase, mitochondrial

PYC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11498
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
6.4.1.1
Processing
Precursor
Secondary accessions
B4DN00, Q16705
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingBiotinManganeseMetal-bindingNucleotide-bindingPyruvate

Disease

Disease variant

Biological process

GluconeogenesisLipid biosynthesisLipid metabolism

Molecular function

LigaseMultifunctional enzyme

Cellular component

Mitochondrion

Domain

Transit peptide

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