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PARK2 rabbit pAb

CAT: 855-ES6479-01Size: 50 µLDry Ice: NoHazardous: No
50 µLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Description
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008],
UniProt
O60260
Swiss Prot
O60260
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Parkin. AA range:1-50
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
52kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
52kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Nucleus . Endoplasmic reticulum . Mitochondrion . Mitochondrion outer membrane . Cell projection, neuron projection . Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Mainly localizes in the cytosol (PubMed:19029340, PubMed:19229105) . Co-localizes with SYT11 in neutrites (PubMed:12925569) . Co-localizes with SNCAIP in brainstem Lewy bodies (PubMed:10319893, PubMed:11431533) . Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051) . Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830) . .
Other Product Names
PARK2; PRKN; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2
Gene ID (Human)
5071

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