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PARK7 rabbit pAb

CAT: 0855-ES3150-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3150-01Size:50 µL
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Background
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Description
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],
Product Name Alternative
PARK7; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7
UniProt
Q99497
Swiss Prot
Q99497
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DJ-1. AA range:21-70
Target
PARK7
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
22kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
22kD
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor . Cytoplasm . Nucleus . Membrane raft . Mitochondrion . Endoplasmic reticulum . Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745) . Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119) . Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. .
Other Product Names
PARK7; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7
Gene ID (Human)
11315

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