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MEF-2C (phospho Ser396) rabbit pAb

CAT: 0855-ES6221-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6221-01Size:50 µL
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Background
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Description
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010],
UniProt
Q06413
Swiss Prot
Q06413
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MEF2C around the phosphorylation site of Ser396. AA range:362-411
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
51kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
51kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm, sarcoplasm .
Other Product Names
MEF2C; Myocyte-specific enhancer factor 2C
Gene ID (Human)
4208

UniProtKB · Q06413

Myocyte-specific enhancer factor 2C

MEF2C_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q06413
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MEF2C
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
C9JMZ0, D7F7N5, F8W7V7
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisDifferentiationNeurogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantEpilepsyIntellectual disability

Technical term

Proteomics identificationReference proteome

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