MEF-2 (phospho Thr312) rabbit pAb

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Background

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) . Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Description

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],

UniProt

Q02078

Swiss Prot

Q02078

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human MEF2A around the phosphorylation site of Thr312. AA range:279-328

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; IP; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus .

Other Product Names

MEF2A; MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1

Gene ID (Human)

4205

UniProtKB · Q02078

Myocyte-specific enhancer factor 2A

MEF2A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q02078
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MEF2A
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B4DFQ7, F6XG23, O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisDifferentiationNeurogenesisTranscriptionTranscription regulation

Disease

Disease variant

Cellular component

Nucleus

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Alternative Products

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A7144-01	MEF-2 (phospho Thr312) Antibody
E28PP0163	MEF-2 (phospho Thr312) Rabbit Polyclonal Antibody
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JOT-AP11224-01	MEF-2(Phospho Thr312) Polyclonal Antibody
E53P04895	MEF-2 Thr312 Rabbit Polyclonal Antibody
PA89700HU-01	Rabbit Anti-Human MEF-2 (phospho Thr312) Polyclonal Antibody
WP9196-01	U-Blot® MEF-2 (phospho Thr312) Polyclonal Antibody
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MBS8585097-01	MLK1/2 (Phospho-Thr312/266) Antibody
AF3630-BP	Phospho-MLK1/2 (Thr312/Thr266) Peptide