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Laminin γ-1 rabbit pAb

CAT: 0855-ES6084-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6084-01Size:50 µL
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Background
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func
Description
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func
UniProt
P11047
Swiss Prot
P11047
Reactivity
Human; Mouse; Rat; Monkey; Cat
Immunogen
The antiserum was produced against synthesized peptide derived from human LAMC1. AA range:1451-1500
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
178kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
178kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Other Product Names
LAMC1; LAMB2; Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Lamini
Gene ID (Human)
3915

UniProtKB · P11047

Laminin subunit gamma-1

LAMC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11047
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LAMC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q5VYE7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Basement membraneExtracellular matrixSecreted

Biological process

Cell adhesion

Domain

Coiled coilLaminin EGF-like domainRepeatSignal

PTM

Disulfide bondGlycoproteinPhosphoprotein

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