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Laminin β-2 rabbit pAb

CAT: 0855-ES6082-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6082-01Size:50 µL
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Background
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func
Description
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func
UniProt
P55268
Swiss Prot
P55268
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human LAMB2. AA range:61-110
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
210kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
210kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane. S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
Other Product Names
LAMB2; LAMS; Laminin subunit beta-2; Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin sub
Gene ID (Human)
3913

UniProtKB · P55268

Laminin subunit beta-2

LAMB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55268
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LAMB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q16321
Protein keywords

Cellular component

Basement membraneExtracellular matrixSecreted

Biological process

Cell adhesion

Domain

Coiled coilLaminin EGF-like domainRepeatSignal

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Technical term

Proteomics identificationReference proteome

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