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FAM111B rabbit pAb

CAT: 0855-ES5990-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5990-01Size:50 µL
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Background
This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP) . Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]
Description
This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12. 1. [provided by RefSeq, Apr 2014],
UniProt
Q6SJ93
Swiss Prot
Q6SJ93
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human F111B. AA range:281-330
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/200. ELISA: 1/5000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Other Product Names
FAM111B; CANP; Protein FAM111B; Cancer-associated nucleoprotein
Gene ID (Human)
374393

UniProtKB · Q6SJ93

Serine protease FAM111B

F111B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6SJ93
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FAM111B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
—
Secondary accessions
B4E2G2, Q6P661
Protein keywords

PTM

AcetylationIsopeptide bondUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Molecular function

HydrolaseProtease

Technical term

Proteomics identificationReference proteome

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Alternative Products

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GTR18215309-01Rabbit FAM111B Antibody
GTR17878171FAM111B Rabbit Polyclonal Antibody
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GTR18531938FAM111B Rabbit Polyclonal Antibody (Cy3)
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GTR18741788FAM111B Rabbit Polyclonal Antibody (Fluoro647)
PAV7176Rabbit Anti-FAM111B Polyclonal Antibody
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