TIN2 rabbit pAb

• Background :

  This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]

• Description :

  This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010],

• UniProt :

  Q9BSI4

• Swiss Prot :

  Q9BSI4

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human TINF2. AA range:71-120

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  53kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  53kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Chromosome, telomere . Associated with telomeres.; [Isoform 1]: Nucleus matrix .

• Other Product Names :

  TINF2; TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2

• Gene ID (Human) :

  26277