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Sck rabbit pAb

CAT: 0855-ES5437-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5437-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:The PID domain mediates binding to the TrkA receptor., function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576., PTM:Phosphorylated on tyrosines by the Trk receptors., similarity:Contains 1 PID domain., similarity:Contains 1 SH2 domain., subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2., tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
Description
Domain: The PID domain mediates binding to the TrkA receptor. function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. miscellaneous: PubMed: 15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed: 12006576. PTM: Phosphorylated on tyrosines by the Trk receptors. similarity: Contains 1 PID domain. similarity: Contains 1 SH2 domain. subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
Product Name Alternative
SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2
UniProt
P98077
Swiss Prot
P98077
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310
Target
Sck
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
59kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
59kD
Fragment
IgG
Subcellular Location
Intracellular, cytosol, plasma membrane
Other Product Names
SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2
Gene ID (Human)
25759

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