APS rabbit pAb
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APS rabbit pAb
Background :
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]Description :
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009],Product Name Alternative :
SH2B2; APS; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APSUniProt :
O14492Swiss Prot :
O14492Reactivity :
Human; Mouse; RatImmunogen :
Synthesized peptide derived from the Internal region of human APS.Target :
APSClonality :
PolyclonalSource :
RabbitApplications :
WB; ELISAConcentration :
1 mg/mlDilution :
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Buffer :
-20°C/1 yearMolecular Weight :
67kDStorage Conditions :
-20°C/1 yearObserved Molecular Weight :
67kDFragment :
IgGSubcellular Location :
Cytoplasm . Cell membrane . Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.Other Product Names :
SH2B2; APS; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APSGene ID (Human) :
10603
