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CD6 rabbit pAb

CAT: 0855-ES4307-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4307-02Size:100 µL
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Background
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Description
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Product Name Alternative
CD6; T-cell differentiation antigen CD6; T12; TP120; CD6
UniProt
P30203
Swiss Prot
P30203
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD6. AA range:361-410
Target
CD6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
73kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
73kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) . Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938) . .; [Soluble CD6]: Secreted . The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. .
Other Product Names
CD6; T-cell differentiation antigen CD6; T12; TP120; CD6
Gene ID (Human)
923

UniProtKB · P30203

T-cell differentiation antigen CD6

CD6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30203
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A4KAD4, A4KAD5, Q8WWJ3, Q8WWJ4, Q8WWJ5, Q8WWJ6, Q8WWJ7, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityCell adhesionImmunityInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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