AID rabbit pAb

• Background :

  This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) . [provided by RefSeq, Feb 2009]

• Description :

  This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009],

• UniProt :

  Q9GZX7

• Swiss Prot :

  Q9GZX7

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from the Internal region of human AICDA. AA range:81-130

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  24kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  24kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Predominantly cytoplasmic (PubMed:21385873) . In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity) . .

• Other Product Names :

  AICDA; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase

• Gene ID (Human) :

  57379