XRCC4 rabbit pAb

• Background:

  The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V (D) J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED) . Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]

• Description:

  The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V (D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015],

• Synonyms:

  XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4

• Gene ID:

  7518

• UniProt:

  Q13426

• Cellular Locus:

  Nucleus. Chromosome. Localizes to site of double-strand breaks..; [Protein XRCC4, C-terminus]: Cytoplasm. Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human XRCC4. AA range:261-310

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  40kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  40kD

• Subcellular Location:

  Nucleus . Chromosome . Localizes to site of double-strand breaks. .; [Protein XRCC4, C-terminus]: Cytoplasm . Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3) . .

• Other Product Names:

  XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4

• Gene ID (Human):

  7518

• SwissProt (Human):

  Q13426