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P140Cap rabbit pAb

CAT: 0855-ES3096-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3096-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells., PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands., similarity:Belongs to the p140Cap family., subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions., subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity) . Interacts with BCAR1/p130Cas through its C-terminal domain.
Description
Function: Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells. PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. similarity: Belongs to the p140Cap family. subcellular location: Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. subunit: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.
Product Name Alternative
SRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
UniProt
Q9C0H9
Swiss Prot
Q9C0H9
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860
Target
P140Cap
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
112kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
112kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cell junction, synapse, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. .
Other Product Names
SRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
Gene ID (Human)
80725

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