Products for Research Use Only
RegisterLogin

NY-CO-9 rabbit pAb

CAT: 0855-ES2994-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES2994-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Product Name Alternative
HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9
UniProt
Q9UQL6
Swiss Prot
Q9UQL6
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HDAC5. AA range:1073-1122
Target
HDAC5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
121kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
121kD
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Other Product Names
HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9
Gene ID (Human)
10014

UniProtKB · Q9UQL6

Histone deacetylase 5

HDAC5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UQL6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HDAC5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HD5
EC number
3.5.1.98
Processing
—
Secondary accessions
C9JFV9, O60340, O60528, Q96DY4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorHydrolaseRepressor

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

Biological process

TranscriptionTranscription regulation

Related Products

CatalogName
ES2993-01NY-CO-1 rabbit pAb
ES4556-01NY-CO-8 rabbit pAb
ES6760-01NY-REN-50 rabbit pAb
ES3202-01PI-9 rabbit pAb
ES2961-01NHE-9 rabbit pAb
ES3155-01Pax-9 rabbit pAb
ES5809-01Anoctamin-9 rabbit pAb
ES2395-01Galectin-9 rabbit pAb
ES20413-01IL-9 rabbit pAb
ES2503-01HDAC5/9 rabbit pAb

Alternative Products

CatalogName
APRab15004-01NY-CO-9 Rabbit Polyclonal Antibody
GTR18050683-01NY-CO-9 rabbit pAb Antibody
PA84521HU-01Rabbit Anti-Human NY-CO-9 Polyclonal Antibody
MBS9512045-01NY-CO-8 Rabbit Polyclonal Antibody
APRab15002-01NY-CO-1 Rabbit Polyclonal Antibody
PA84520HU-01Rabbit Anti-Human NY-CO-1 Polyclonal Antibody
PA88648HU-01Rabbit Anti-Human NY-CO-8 Polyclonal Antibody
GTR18212455CO (M) Antibody, Rabbit Polyclonal
GTR18212429CO (C) Antibody, Rabbit Polyclonal
A9810-01NY-ESO-1 Rabbit pAb

Popular Products