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MYSM1 rabbit pAb

CAT: 0855-ES2883-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2883-01Size:50 µL
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Background
Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA., function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the peptidase M67A family. MYSM1 subfamily., similarity:Contains 1 MPN (JAB/Mov34) domain., similarity:Contains 1 SANT domain., similarity:Contains 1 SWIRM domain., subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.
Description
Catalytic activity: Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol. Domain: Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA. function: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the peptidase M67A family. MYSM1 subfamily. similarity: Contains 1 MPN (JAB/Mov34) domain. similarity: Contains 1 SANT domain. similarity: Contains 1 SWIRM domain. subunit: Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.
UniProt
Q5VVJ2
Swiss Prot
Q5VVJ2
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
95kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Localizes to the cytoplasm in response to bacterial infection. .
Other Product Names
MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1
Gene ID (Human)
114803

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