MLTK rabbit pAb

• Description:

  This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

• Synonyms:

  MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe

• Gene ID:

  51776

• UniProt:

  Q9NYL2

• Cellular Locus:

  Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human MLTK. AA range:701-750

• Clonality:

  Polyclonal

• Validated Applications:

  WB, IHC

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000;IHC-p 1:50-300

• Molecular Weight:

  91kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.