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KCNH1 rabbit pAb

CAT: 0855-ES2669-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided
Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided
Product Name Alternative
KCNH1; EAG; EAG1; Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1
UniProt
O95259
Swiss Prot
O95259
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNH1. AA range:720-769
Target
KCNH1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic density membrane . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.
Other Product Names
KCNH1; EAG; EAG1; Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1
Gene ID (Human)
3756

UniProtKB · O95259

Voltage-gated delayed rectifier potassium channel KCNH1

KCNH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95259
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KCNH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B1AQ26, O76035, Q14CL3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Calmodulin-bindingIon channelPotassium channelVoltage-gated channel

Cellular component

Cell membraneCell projectionEndosomeMembraneNucleusPostsynaptic cell membraneSynapse

Disease

Disease variantEpilepsyIntellectual disability

PTM

GlycoproteinPhosphoprotein

Biological process

Ion transportPotassium transportTransport

Ligand

Lipid-bindingPotassium

Domain

TransmembraneTransmembrane helix

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