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JMY rabbit pAb

CAT: 0855-ES2661-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2661-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage., induction:By E2F., PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response., similarity:Contains 1 WH2 domain., subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.
Description
Function: Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. induction: By E2F. PTM: Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response. similarity: Contains 1 WH2 domain. subunit: Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.
Product Name Alternative
JMY; Junction-mediating and -regulatory protein
UniProt
Q8N9B5
Swiss Prot
Q8N9B5
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human JMY. AA range:931-980
Target
JMY
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane . Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity) . In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355
Other Product Names
JMY; Junction-mediating and -regulatory protein
Gene ID (Human)
133746

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