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HURP rabbit pAb

CAT: 0855-ES2586-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2586-01Size:50 µL
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Background
Developmental stage:Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells., function:Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells., PTM:Ubiquitinated, leading to its degradation., similarity:Belongs to the SAPAP family., subcellular location:Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells., subunit:Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1., tissue specificity:Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Description
Developmental stage: Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. function: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. PTM: Ubiquitinated, leading to its degradation. similarity: Belongs to the SAPAP family. subcellular location: Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. subunit: Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1. tissue specificity: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Product Name Alternative
DLGAP5; DLG7; KIAA0008; Disks large-associated protein 5; DAP-5; Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein; HURP
UniProt
Q15398
Swiss Prot
Q15398
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DLGAP5. AA range:791-840
Target
HURP
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
95kD
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Other Product Names
DLGAP5; DLG7; KIAA0008; Disks large-associated protein 5; DAP-5; Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein; HURP
Gene ID (Human)
9787

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