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HLA-DOβ rabbit pAb

CAT: 0855-ES2537-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2537-02Size:100 µL
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Background
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Description
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
Product Name Alternative
HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
UniProt
P13765
Swiss Prot
P13765
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50
Target
HLA-DOβ
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
30kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
30kD
Fragment
IgG
Subcellular Location
Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Other Product Names
HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
Gene ID (Human)
3112

UniProtKB · P13765

HLA class II histocompatibility antigen, DO beta chain

DOB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13765
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-DOB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B0V0Y0, Q29746, Q29825, Q6FHC2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

PTM

Disulfide bondGlycoprotein

Cellular component

EndosomeLysosomeMembraneMHC II

Domain

SignalTransmembraneTransmembrane helix

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