HLA-DMβ rabbit pAb

HLA-DMβ rabbit pAb

• Description: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
• Synonyms: HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB;Really interesting new gene 7 protein)
• Gene ID: 3109
• UniProt: P28068
• Cellular Locus: Late endosome membrane ; Single-pass type I membrane protein. Lysosome membrane ; Single-pass type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide from human protein at AA range: 40-100
• Clonality: Polyclonal
• Validated Applications: IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.