HLA-DOα Rabbit Polyclonal Antibody

• Background:

  HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008], function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule., polymorphism:The only allele of DOA known is DOA*0101 which is shown here., similarity:Belongs to the MHC class II family., similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain., subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB) .

• Product Name Alternative:

  HLA-DOA; HLA-DNA; HLA-DZA; HLA class II histocompatibility antigen; DO alpha chain; MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA

• Gene Name:

  HLA-DOA

• Gene ID:

  3111

• Swiss Prot:

  P06340

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, ELISA

• Field of Research:

  Cell adhesion molecules (CAMs) ; Antigen processing and presentation; Intestinal immune network for IgA production; Type I diabetes mellitus; Asthma; Autoimmune thyroid disease; Systemic lupus erythematosus; Allograft rejection; Graft-versus-host disease; Viral myocarditis

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  34kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG