Products for Research Use Only
RegisterLogin

HLA-DPα1 rabbit pAb

CAT: 0855-ES5741-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES5741-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Description
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008],
Product Name Alternative
HLA-DPA1; HLA-DP1A; HLASB; HLA class II histocompatibility antigen; DP alpha 1 chain; DP (W3) ; DP (W4) ; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1
UniProt
P20036
Swiss Prot
P20036
Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of human HLA-DPα1.
Target
HLA-DPα1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
29kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
29kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Other Product Names
HLA-DPA1; HLA-DP1A; HLASB; HLA class II histocompatibility antigen; DP alpha 1 chain; DP (W3) ; DP (W4) ; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1
Gene ID (Human)
3113

UniProtKB · P20036

HLA class II histocompatibility antigen, DP alpha 1 chain

DPA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20036
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-DPA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A9YWH7, B9UKH4, O19722, O46883, P01905, P79554, Q2Q060, Q2Q061, Q5EY03, Q5STP1, Q6DQK4, Q9BCQ1, Q9TPX3, Q9XS10
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneMHC II

PTM

Disulfide bondGlycoprotein

Domain

SignalTransmembraneTransmembrane helix

Related Products

CatalogName
ES2195-01DP-2 rabbit pAb
ES2537-01HLA-DOβ rabbit pAb
ES5742-01HLA-H rabbit pAb
ES8783-01HLA-DMβ rabbit pAb
ES2536-01HLA-DOα rabbit pAb
ES8761-01HLA-DQA1 rabbit pAb
ES4222-01HLA-DQB1/2 rabbit pAb
ES8555-01HLA Class I rabbit pAb
ES4354-01SIRP-α1/β1 rabbit pAb
ES20692-01Kininogen 1 Rabbit rabbit pAb

Alternative Products

CatalogName
MBS4764125-01HLA-DP Rabbit mAb
GTR18052129-01HLA-DPα1 rabbit pAb Antibody
E28PT2179HLA-DPα1 Rabbit Polyclonal Antibody
PAV7941Rabbit Anti-HLA-DPα1/HLA-DPA1 Polyclonal Antibody
TA342062HLA DP (HLA-DPA1) Rabbit Polyclonal Antibody
GB113093-100Anti-HLA-DP Rabbit pAb
GTR18702942-01HLA-DP Rabbit Monoclonal Antibody
PA89339HU-01Rabbit Anti-Human HLA-DPα1 Polyclonal Antibody
CMA1116-01Recombinant Anti-HLA-DP Rabbit mAb
MA3044-.05Anti-HLA-DP Rabbit Monoclonal Antibody

Popular Products