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HDAC8 rabbit pAb

CAT: 0855-ES2506-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2506-02Size:100 µL
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Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
UniProt
Q9BY41
Swiss Prot
Q9BY41
Reactivity
Human; Mouse; Rat; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human HDAC8. AA range:5-54
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
42kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
42kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Cytoplasm . Excluded from the nucleoli (PubMed:10748112) . Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051) . .
Other Product Names
HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8
Gene ID (Human)
55869

UniProtKB · Q9BY41

Histone deacetylase 8

HDAC8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BY41
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HDAC8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HD8
EC number
3.5.1.98
Processing
—
Secondary accessions
A6ND12, A6ND61, A6NET3, A6NJR3, A8MQ62, B4DKN0, B4DV22, Q86VC8, Q9NP76, Q9NYH4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorHydrolaseRepressor

Cellular component

ChromosomeCytoplasmNucleus

Disease

Disease variantIntellectual disabilityObesity

Ligand

Metal-binding

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

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