HDAC5 rabbit pAb

CAT: 0855-ES2502-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES2502-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q9UQL6
Swiss Prot
Q9UQL6
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human HDAC5. AA range:464-513
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
122kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
122kD
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Other Product Names
HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9
Gene ID (Human)
10014

Related Products

CatalogName
ES2503-01HDAC5/9 rabbit pAb
ES1324-01HDAC5 (phospho Ser498) rabbit pAb
ES4406-01HDAC5/9 (phospho Ser259/220) rabbit pAb
ES2501-01HDAC4 rabbit pAb
ES2500-01HDAC3 rabbit pAb
ES2505-01HDAC7 rabbit pAb
ES2499-01HDAC2 rabbit pAb
ES2498-01HDAC1 rabbit pAb
ES2504-01HDAC6 rabbit pAb
ES2506-01HDAC8 rabbit pAb

Alternative Products

CatalogName
MBS8547942-01HDAC5 Rabbit pAb
E60M3909HDAC5 Rabbit mAb
TA384402HDAC5 Rabbit Polyclonal Antibody
APR27183N-01HDAC5 Rabbit pAb (APR27183N)
NBP3-29402Rabbit Polyclonal HDAC5 Antibody
523780-01HDAC5

Popular Products