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Emp rabbit pAb

CAT: 0855-ES2258-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2258-02Size:100 µL
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Background
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Description
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
UniProt
Q7L5Y9
Swiss Prot
Q7L5Y9
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MAEA. AA range:181-230
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
45kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
45kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix . Cell membrane . Cytoplasm, cytoskeleton . Detected in a nuclear, speckled-like pattern (PubMed:16510120) . Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120) . Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity) . .
Other Product Names
MAEA; EMP; HLC10; PIG5; Macrophage erythroblast attacher; Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10
Gene ID (Human)
10296

UniProtKB · Q7L5Y9

E3 ubiquitin-protein transferase MAEA

MAEA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7L5Y9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAEA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
O95285, Q5JB54, Q6ZRD6, Q9BQ11, Q9H9V6, Q9H9Z4, Q9NW84
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingTransferase

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionErythrocyte maturationUbl conjugation pathway

Cellular component

Cell membraneCytoplasmCytoskeletonMembraneNucleus

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Domain

Zinc-finger

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