D4DR rabbit pAb

• Background:

  This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

• Description:

  This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008],

• UniProt:

  P21917

• Swiss Prot:

  P21917

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  48kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  48kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein .

• Other Product Names:

  DRD4; D (4) dopamine receptor; D (2C) dopamine receptor; Dopamine D4 receptor

• Gene ID (Human):

  1815