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Connexin-26 rabbit pAb

CAT: 0855-ES2029-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2029-01Size:50 µL
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Background
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
Description
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008],
Product Name Alternative
GJB2; Gap junction beta-2 protein; Connexin-26; Cx26
UniProt
P29033
Swiss Prot
P29033
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin-26. AA range:45-94
Target
Connexin-26
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
26kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Colocalizes with GJB4 at gap junction plaques in the cochlea. .
Other Product Names
GJB2; Gap junction beta-2 protein; Connexin-26; Cx26
Gene ID (Human)
2706

UniProtKB · P29033

Gap junction beta-2 protein

CXB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P29033
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GJB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q508A5, Q508A6, Q5YLL0, Q5YLL1, Q5YLL4, Q6IPV5, Q86U88, Q96AK0, Q9H536, Q9NNY4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

Cell junctionCell membraneGap junctionMembrane

Disease

DeafnessDisease variantEctodermal dysplasiaIchthyosisNon-syndromic deafnessPalmoplantar keratoderma

PTM

Disulfide bond

Biological process

Hearing

Domain

TransmembraneTransmembrane helix

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