Products for Research Use Only
RegisterLogin

Connexin 43 rabbit pAb

CAT: 0855-ES2028-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES2028-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Description
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014],
UniProt
P17302
Swiss Prot
P17302
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin 43. AA range:333-382
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Molecular Weight
43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
43kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Endoplasmic reticulum . Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. .
Other Product Names
GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein
Gene ID (Human)
2697

UniProtKB · P17302

Gap junction alpha-1 protein

CXA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17302
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GJA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R5U9, Q6FHU1, Q9Y5I8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Disease

CataractDisease variantHypotrichosisPalmoplantar keratoderma

Cellular component

Cell junctionCell membraneEndoplasmic reticulumGap junctionMembrane

Biological process

ImmunityInnate immunity

Domain

TransmembraneTransmembrane helix

Related Products

CatalogName
ES5522-01Connexin 43 (phospho Ser261) rabbit pAb
ES5521-01Connexin 43 (phospho Tyr265) rabbit pAb
ES1291-01Connexin 43 (phospho Ser368) rabbit pAb
ES5523-01Connexin 43 Rabbit Polyclonal Antibody
ES2027-01Connexin 25 rabbit pAb
ES4416-01Connexin 45 rabbit pAb
ES5527-01Connexin 46 rabbit pAb
ES4417-01Connexin-45 rabbit pAb
ES4107-01Connexin-40 rabbit pAb
ES5528-01Connexin 37 rabbit pAb

Alternative Products

CatalogName
A23928Connexin 43 Rabbit PolymAb®
A23302Connexin 43 Rabbit mAb
GTR10376403Rabbit Connexin ELISA kit
GTR18600066-01Connexin 43 Rabbit pAb
GTR18603685-01Connexin 37 Rabbit pAb
E47R6474Connexin 30 Rabbit pAb
E47R1376Connexin-32 Rabbit pAb
E47R1050Connexin-40 Rabbit pAb
E2R389385Connexin 32 Rabbit mAb
E47R1266Connexin-36 Rabbit pAb

Popular Products