CCRL1 rabbit pAb
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CCRL1 rabbit pAb
Background:
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]Description:
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013],UniProt:
Q9NPB9Swiss Prot:
Q9NPB9Reactivity:
Human; MouseImmunogen:
The antiserum was produced against synthesized peptide derived from human CCRL1. AA range:5-54Clonality:
PolyclonalSource:
RabbitApplications:
WB; IF; ELISAConcentration:
1 mg/mlDilution:
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.Molecular Weight:
40kDStorage Conditions:
-20°C/1 yearObserved Molecular Weight:
40kDFragment:
IgGSubcellular Location:
Early endosome . Recycling endosome . Cell membrane ; Multi-pass membrane protein . Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.Other Product Names:
CCRL1; CCBP2; CCR11; VSHK1; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKRGene ID (Human):
51554