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CB2 rabbit pAb

CAT: 0855-ES1874-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1874-01Size:50 µL
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Background
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein) -coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Description
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008],
UniProt
P34972
Swiss Prot
P34972
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CNR2. AA range:191-240
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
33kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
33kD
Fragment
IgG
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite . Perikaryon . Localizes to apical dendrite of pyramidal neurons. .
Other Product Names
CNR2; Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5
Gene ID (Human)
1269

UniProtKB · P34972

Cannabinoid receptor 2

CNR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P34972
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CB-2, CB2, hCB2
EC number
—
Processing
—
Secondary accessions
C6ES44, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCell projectionMembrane

Molecular function

G protein-coupled receptorReceptorTransducer

PTM

GlycoproteinPhosphoprotein

Biological process

Inflammatory response

Domain

TransmembraneTransmembrane helix

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